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Hollow Fibre Modules:

• MicroKros

• MidiKros

• MiniKros Sampler

• MiniKros Sampler Plus

• MiniKros

• MiniKros Plus

• KrosFlo

• KrosFlo Plus

ŧ KrosFlo Max

• CellFlo

• CellFlo Plus

• CellFlo Max

• KrosFlo SIP

 

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KrosFlo Max Modules

Production Scale Hollow Fibre Modules for Processing 50 to 5000 L

Overview

KrosFlo Max and CellFlo Max are the largest hollow fibre filter modules available for the bioprocessing and pharmaceutical industries. These production modules directly scale up from KrosFlo Plus and CellFlo Plus to provide surface areas ranging from 5.3 to 22 m². KrosFlo Max and CellFlo Max modules can be operated with the KrosFlo Pharma system or a custom-designed skid to combine and maximize the advantages of gentle hollow fibre flow dynamics, the efficiency of tangential flow filtration, the time and cost savings of disposability.

Disposable KrosFlo Max are available in three convenient sizes. The "300" size provides a direct scale-up of the process volume, flow rate and permeate rate from KrosFlo Plus "3X" size. The "600" and "800" sizes are easy retrofits for commercially available re-usable modules. All three sizes can be connected to any process loop via 2" sanitary retentate ports and 1.5" sanitary filtrate ports. Non-irradiated modules can be sterilized once prior to use by autoclaving, irradiation or ETO.

Modules are manufactured under cGMP in an ISO class 20 E (US Fed. Class 10,000) cleanroom and are 100% integrity tested and 100% lot traceable. All material of construction meet class VI biocompatibility standards.

KrosFlo Max Modules


KrosFlo Max Modules

Applications

• Cell lysate clarification
• Microparticle diafiltration
• Nanoparticle diafiltration
• E. coli concentration
• Fermentation harvest
• Macrophage clarification
• Bacculovirus, retrovirus and
adenovirus purification

• Viral removal
• Antibody purification (IgM & IgG)
• Protein concentration
• Buffer exchange, pH change, desalt
• Albumin purification
• Depyrogenation
• Small protein and peptide purification

Specification

Parameter Description
Housing Clear and pigmented polysulfone
Netting Polypropylene
Flange Nut Pigmented polysulfone
Inlet/Outlet Reducer 2" sanitary, clear polysulfone
Filtration Side-Port 1.5" sanitary
Potting Polyurethane
Process Volume 50 - 5000 L
Surface Area 6.3 - 22 mē

Membranes Fibre ID MWCO
Mixed Cellulose Ester (ME) 0.6 mm 0.1 µm, 0.2 µm
Polyethersulfone (PES) 0.5 mm 0.2 µm, 0.5 µm
Polysulfone (PS) 0.5 mm 0.05µm, 20 nm, 400 kD, 100 kD, 50 kD, 10 kD

Surface Area (m²) Module Size D (mm) TL (cm) L (cm) EL (cm)
6.3 - 10.2 xxxx-600-xxx 11.6 73.5 62.8 49.9
9.3 - 13.9 xxxx-300-xxx 11.6 91.5 81.2 67.9
13.5 - 22.0 xxxx-800-xxx 11.6 131.1 120.6 107.5
 

Please contact us for current prices, more technical details or assistance.

Phone (403) 287-2345 • Toll-free 1-(800)-565-2345 • Fax (403) 287-1355 • E-mail: sincaninc@telus.net

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